Table 11 Effect of transsphenoidal surgery in clinically nonfunctioning adenomas on pituitary function.
No. of patients | Time after surgery for evaluation of pituitary function (months) | Suprasellar extension (%) Parasellar/infrasellar extension (%) | Pituitary: preoperative function | Pituitary: postperative function | |
|---|---|---|---|---|---|
GH deficiency (%) | GH deficiency (%) | ||||
LH/FSH deficiency (%) | LH/FSH deficiency (%) | ||||
TSH deficiency (%) | TSH deficiency (%) | ||||
ACTH deficiency (%) | ACTH deficiency (%) | ||||
Hypopituitarism (%) | Hypopituitarism (%) | ||||
Arafah et al. (6) | 26 | 0.2 | 80 | 100 | 85 |
ND | 96 | 65 | |||
81 | 35 | ||||
62 | 38 | ||||
ND | ND | ||||
Dekkers et al. (12) | 109 | 6 | 96 | 77 | 83 |
36 | 75 | 90 | |||
43 | 57 | ||||
53 | 60 | ||||
83 | 94 | ||||
Nomikos et al. (8) | 660 | 12 | ND | ND | ND |
ND | 77 | 65 | |||
19 | 16 | ||||
35 | 18 | ||||
85 | 72 | ||||
Alameda et al. (3) | 51 | ND | 82 | 80 | 88 |
48 | 62 | 57 | |||
21 | 27 | ||||
19 | 19 | ||||
85 | 89 | ||||
Wichers-Rother et al. (2) | 109 | 1–6 | ND | 85 | 78 |
ND | 61 | 50 | |||
31 | 34 | ||||
32 | 25 | ||||
ND | ND | ||||
Marazuela et al. (4) | 35 | 2–6 | 80 | 88 | 82 |
84 | 69 | 48 | |||
23 | 20 | ||||
29 | 13 | ||||
69 | ND | ||||
Comtois et al. (7) | 126 | ND | 94 | ND | ND |
33 | 75 | 70 | |||
18 | 31 | ||||
36 | 29 | ||||
73 | ND | ||||
Greenman et al. (31) | 26 | 3–6 | 96 | ND | ND |
42 | 78 | 46 | |||
23 | 12 | ||||
43 | 50 | ||||
89 | 65 |
