Figure 1 | Scientific Reports

Figure 1

From: Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Figure 1

Administration of HSA increase survival of mutant mice.

Kaplan-Meier survival curve of FVB/NJ Ugt1 mutant mice. Mutant mice were treated with IP injections of albumin (2.5, 5.0 and 7.5 g/kg) from P2 to P20 every 24 h or 48 h, as indicated. The line color/type indicates the different treatments (red line, untreated mutant mice; orange line, mutant mice treated with phototherapy from P0 to P10; other lines, HSA treatments). p < 0.0001, Log-rank (Mantel-Cox) test. The number of animals per treatment is as follows: UNTR (n = 21), P0-P10 PT (n = 24), HSA 2.5 g/kg/48 h (n = 15), HSA 2.5 g/kg/24 h (n = 11), HSA 5.0 g/kg/48 h (n = 15), HSA 5.0 g/kg/24 h (n = 15), HSA 7.5 g/kg/24 h (n = 12) UNTR, untreated mice; HSA, human serum albumin; PT, phototherapy; P, post-natal day.

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