Figure 3 | Scientific Reports

Figure 3

From: Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Figure 3

Effect of albumin supplementation on tissue bilirubin-binding and Bf.

(A) Brain UCB levels (forebrain and cerebellum) in P0-P10 PT (n = 8), HSA 5.0 g/kg/48 h (n = 6) and HSA 5.0 g/kg/24 h (n = 7)-treated mutant mice at P15. Values represent mean ± SD (nmol/mg). One-way ANOVA test, **p < 0.01, ***p < 0.001. (B) Free bilirubin (Bf) analysis in plasma in P0-P10 PT (n = 19), HSA 5.0 g/kg/48 h (n = 9) and HSA 5.0 g/kg/24 h (n = 8) mutant mice at P15. Values represent mean ± SD (μg/dL). One-way ANOVA test, ***p < 0.001 HSA, human serum albumin; PT, phototherapy; P, post-natal day; UCB, unconjugated bilirubin; ns, not significative.

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