Table 1 Plasma total bilirubin and albumin levels. ND, not determined as untreated mutant mice do not survive up to P30.

From: Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Treatment

Age

TB (mg/dL)

Plasma albumin (g/L)

WT

MUT

WT

MUT

P0-P10 PT

P15

0.2 ± 0.1 (20)

14.9 ± 1.6 (21)***

16.2 ± 1.8 (20)

15.7 ± 2.1 (21) ns

HSA 2.5 g/kg/24h

P15

0.6 ± 0.1 (5)

28.8 ± 2.6 (7)***

22.9 ± 0.5 (5)

24.1 ± 1.4 (7) ns

HSA 5.0 g/kg/48h

P15

0.5 ± 0.1 (4)

24.3 ± 2.6 (15)***

26.1 ± 1.4 (4)

26.4 ± 2.6 (15) ns

HSA 5.0 g/kg/24h

P15

0.7 ± 0.1 (5)

25.1 ± 2.8 (15)***

27.4 ± 2.9 (5)

28.9 ± 2.2 (15) ns

HSA 7.5 g/kg/24h

P15

1.7 (1)

29.4 ± 1.6 (3)

35.9 ± 0 (1)

35.3 ± 1.1 (3)

P0-P10 PT

P16

0.2 ± 0.1 (7)

19.3 ± 3.5 (6)***

16.2 ± 1.1 (7)

15.8 ± 2.8 (6) ns

HSA 5.0 g/kg/48h

P16

0.3 ± 0.2 (7)

27.7 ± 2.8 (14)***

24.2 ± 4.2 (7)

21.7 ± 4.1 (14) ns

HSA 5.0 g/kg/24h

P16

0.8 ± 0.2 (6)

31.2 ± 4.2 (7)***

29.1 ± 4.4 (6)

29.5 ± 4.6 (7) ns

Untreated

P30

0.1 ± 0.1 (4)

ND

18.3 ± 1.8 (4)

ND

HSA 5.0 g/kg/24h

P30

0.1 ± 0.1 (5)

8.2 ± 1.2 (7)***

19.2 ± 1.5 (7)

16.7 ± 2.0 (7) ns

HSA 7.5 g/kg/24h

P30

0.1 ± 0.1 (5)

7.4 ± 1.05 (6)***

18.7 ± 2.3 (6)

17.9 ± 1.7 (6) ns

  1. The number of animals is indicated between parenthesis. *** indicates a p < 0.001 (t-test between WT and treated mutant mice, within each treatment).
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