Table 2 Effect of P2X7 knockdown on the synergy between Ivermectin and ATP.

From: Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

CI values

<0.8 Synerg

0.8-1.2 Addit

>1.2 Antag

4T1.2 shRNA (P2×7)

 

I 6

I 8

I 10

ATP 1

1.49

1.39

1.35

ATP 2

1.18

1.03

1.11

ATP 3

0.96

0.91

0.86

4T1.2 shRNA (NT)

ATP 1

1.18

1.01

1.24

ATP 2

1.17

1.01

1.10

ATP 3

0.67

0.64

0.63

Back to article page