Figure 5 | Scientific Reports

Figure 5

From: Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

Figure 5

In vivo combination treatment of AML mice with cyclophosphamide (CTX) and E5.

(A) The percentage of CD33 positive cells (HL-60) in the bone marrow, spleen and peripheral blood of AML mice in each group was determined with flow cytometry. Data are presented as mean ± SD (n = 4). The * represents significant difference between two groups (*p < 0.05, **p < 0.01). (B) Wright-stained peripheral blood smears of AML mice in each group. Yellow arrows represent HL-60 cells. Scale bar represents 50 μm. (C) Overall survival of AML mice treated with sterile water, E5 alone, CTX alone, or a combination of both (n = 9). (D) Relative weight of the mice during the period of treatment.

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