Figure 4 | Scientific Reports

Figure 4

From: IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

Figure 4

Synopsis of how IDH mutation status is linked to angiogenesis and alteration in rCBV on DSC-MRI in human glioma based on this hypothesis generating study.

In brief, mutations in cancer-associated IDH acquire neoactivity producing 2-hydroxyglutarate (2HG). (R)-2HG potentiates EglN activity that mark the hypoxia inducible factor HIF1A for polyubiquitylation and proteasomal degradation, leading to decreased HIF1A activation in IDH mutant tumors, compared with their wild-type counterparts. This results in a distinct transcriptome signature induced by upregulation of hypoxia, vasculo- and angiogenesis related signaling pathways in IDH wild-type tumors, which is non-invasively detectable with rCBV imaging.

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