Table 1 Ingenuity pathway analysis of upstream regulators (A) and downstream biological functions (B).

From: IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

(A) Upstream regulators in IDH-1/2 mutant tumors

Upstream regulator

Molecule type

p value of overlap

Activation z score

Predicted activation state

Vegf

Group

4.11E-30

−7.287

Inhibited

PDGF BB

Complex

3.94E-36

−5.17

Inhibited

HIF1A

Transcription regulator

6.54E-10

−4.65

Inhibited

VEGFA

Growth factor

1.27E-10

−4.306

Inhibited

Pdgf

Complex

2.94E-10

−3.646

Inhibited

ANGPT2

Growth factor

6.79E-09

−3.361

Inhibited

(B) Downstream biological functions in IDH-1/2 mutant tumors

Biological function

p value of overlap

Activation z score

Predicted activation state

Development of blood vessel

7.87E-30

−4.185

Decreased

Migration of endothelial cells

3.26E-15

−3.799

Decreased

Vasculogenesis

8.89E-28

−3.717

Decreased

Movement of endothelial cells

2.66E-16

−3.540

Decreased

Angiogenesis

9.39E-28

−3.556

Decreased

Neovascularization

1.53E-10

−2.451

Decreased

Vascularization

6.85E-12

−2.319

Decreased

Development of endothelial cells

6.58E-12

−2.020

Decreased

  1. Both concordantly demonstrate a significant decrease in key angiogenic regulators such as HIF1A, VEGFA, PDGF or ANGPT2 (A) and consequently angiogenic biological processes (B) in IDH-1/2 mutant tumors. Full results are available in the data supplement (Supplementary Table 3).
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