Table 2 Information of the SNPs previously reported to be associated with the risk of HBV- and HCV-related HCC by GWASs.

Chr.	Related gene	Distance to gene	Position	SNP	Allele^a	Risk allele^b	RAF in CHB	Ref.
1	KIF1B	Intron 24	10308058	rs17401966	G/A	A	0.733	¹⁰
2	STAT4	Intron 3	191672878	rs7574865	T/G	G	0.650	¹³
3	GLB1	18 kb upstream	32995039	rs4678680	G/T	G	0.037	⁹
6	C2	12 kb upstream	31991658	rs9267673	T/C	T	0.159	⁹
6	HLA-DRB1	16 kb downstream	32681992	rs2647073	C/A	C	0.098	⁹
6	HLA-DRB1	23 kb downstream	32688595	rs3997872	A/T	A	0.037	⁹
6	HLA-DQA1/DRB1	96kb downstream of HLA-DQA1	32707977	rs9272105	G/A	A	0.524	¹²
6	HLA-DQ	42 kb downstream of HLA-DQB2	32774273	rs9275319	G/A	A	0.783^c	¹³
6	BACH2	Intron 5	90791705	rs7749730	G/A	A	0.890	⁹
8	—	—	37548149	rs12682266	A/G	G	0.488	¹¹
14	C14orf143	Intron 5	89370788	rs12100561	A/G	A	0.366	⁹
21	GRIK1	Intron 1	30068040	rs455804	A/C	C	0.683	¹²
6	MICA	4.7 kb upstream	31474574	rs2596542	T/C	T	0.256	¹⁵
6	HLA-DQA2	Intron 1	32786977	rs9275572	A/G	A	0.317	¹⁵
22	DEPDC5	Intron 32	30595903	rs1012068	G/T	G	0.134	¹⁶

Chr. chromosome; RAF, risk allele frequency; CHB, Chinese Han in Beijing from in HapMap.
^aMinor allele/major allele.
^bRisk allele means the allele associated with increased risk of HBV-related HCC in the original GWAS.
^CAllele frequency in CHB+JPT in HapMap.

Quick links

Search