Table 3 Results of association between SNPs previously reported by HBV-related HCC GWAS and the risk of progression from CHB to LC.

From: Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

Gene

SNP

Allelea

RAFb of Shanghai cohort

RAFb of Beijing cohort

ORmeta (95% CI)c,d

P meta c

Pmeta-Adjustede

P het.

Cases

Controls

Cases

Controls

KIF1B

rs17401966

G/A

0.33

0.29

0.28

0.28

1.13 (0.99–1.30)

8.03 × 10−2

1.64 × 10−1

0.522

STAT4

rs7574865

T/G

0.72

0.67

0.72

0.69

1.17 (1.03–1.34)

1.79 × 10−2

4.18 × 10−2

0.894

GLB1

rs4678680

G/T

0.94

0.93

0.92

0.93

1.13 (0.87–1.47)

3.45 × 10−1

4.57 × 10−1

0.958

C2

rs9267673

T/C

0.17

0.12

0.13

0.12

1.37 (1.15–1.63)

4.91 × 10−4

1.74 × 10−3

0.680

HLA-DRB1

rs2647073

C/A

0.09

0.05

0.10

0.08

1.63 (1.29–2.06)

3.53 × 10−5

3.75 × 10−4

0.886

HLA-DRB1

rs3997872

A/T

0.97

0.94

0.97

0.95

1.86 (1.32–2.62)

4.22 × 10−4

1.66 × 10−3

0.997

HLA-DQA1/DRB1

rs9272105

A/G

0.43

0.41

0.42

0.39

1.07 (0.95–1.20)

2.59 × 10−1

3.87 × 10−1

0.981

HLA-DQ

rs9275319

G/A

0.91

0.89

0.93

0.90

1.32 (1.06–1.64)

1.30 × 10−2

3.36 × 10−2

0.989

BACH2

rs7749730

G/A

0.17

0.15

0.15

0.17

1.06 (0.89–1.26)

5.14 × 10−1

5.56 × 10−1

0.387

–

rs12682266

A/G

0.50

0.50

0.47

0.46

1.01 (0.89–1.14)

8.97 × 10−1

6.86 × 10−1

1.000

C14orf143

rs12100561

A/G

0.41

0.40

0.39

0.41

1.00 (0.88–1.14)

9.42 × 10−1

6.96 × 10−1

0.952

GRIK1

rs455804

A/C

0.33

0.32

0.29

0.32

1.00 (0.87–1.15)

9.88 × 10−1

7.06 × 10−1

0.831

  1. RAF, risk allele frequency; OR, odds ratio; CI, confidence interval.
  2. aMinor allele/major allele.
  3. bRAF means the allele frequency of cases is lower than that of controls in the Shanghai cohort or both of the two cohorts.
  4. cThe data was analyzed by meta-analysis using the fixed-effects model (the Mantel-Haenszel model) based on the association results, which were generated by logistic regression analysis under an additive model adjusting for gender and age in the two cohorts.
  5. dThe ORs and 95%CIs were calculated by considering the non-risk allele as a reference.
  6. eFalse discovery rate (FDR) correction for multiple testing.
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