Figure 1
From: Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly
Phenotypic characterization of the acromegaly-like GC rat model.
(A) Left panel. Representative picture of a rat (right) bearing a GC tumor (circled in red dashed lines) 8 weeks after subcutaneous injection of GC cells compared to a vehicle-treated rat (left). Right panel. (B) Increase in body weight after subcutaneous injection of GC cells compared to PBS-injected control rats. Removal of the tumor by surgery blocks the increase in body weight. P < 0.0001. Error bars missing in B is due to the small size of s.e.m. in those data points (C) Survival curve of GC tumor-bearing and control rats. GC tumor-bearing rats display increase mortality life expectancy as compared to both tumorectomized and vehicle-treated rats (logrank test’s P < 0.001) (D) Increased heart size in GC tumor-bearing rats (9 weeks after GC cells implantation) compared to compared to both tumorectomized (4 weeks after tumor resection) and vehicle-treated rats. Increased blood GH (E) and IGF-I levels (F) compared to both tumorectomized (4 weeks after tumor resection and vehicle-treated rats. n = 5 samples per group. Data are mean ± s.e.m. *P < 0.05.
