Figure 2 | Scientific Reports

Figure 2

From: (Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

Figure 2

TMS significantly induced apoptosis in H1975 and suppressed the mTOR pathway.

(a) The morphological changes of H1975 cells after treatment of TMS. (b) Flow cytometric analysis of the apoptosis level after TMS treatment. Statistical analysis result of b. (c) PARP and caspase-3 were cleaved and activated by TMS, while Bcl-2 was downregulated. (d) The result of proteomics showed that mTOR pathway was inhibited by TMS. (e) Western-blot result confirmed that TMS selectively inhibited mTOR pathway in G-R NSCLC cells H1975 and H820, but no effect on normal lung epithelial cells BEAS-2B. (*p < 0.05, **p < 0.01, ***p < 0.001).

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