Figure 7 | Scientific Reports

Figure 7

From: (Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

Figure 7

TMS inhibited EGFR activation by regulating [Ca2+] level.

(a) TMS specifically inhibited the phosphorylation of tyrosine residue 1173 on EGFR in G-R NSCLC cells. (b) TMS has no effect on EGFR in EGFR wild-type NSCLC cells: A549 and H358 and normal lung epithelial cells BEAS-2B. (c) TMS also inhibited the activation of EGFR downstream pathways. (d) The proposed framework of TMS action on H1975 cells.

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