Table 2 A table showing the compressibility of the powders as analysed through out-of-die and in-die Heckel Analysis, with yield pressures giving an indication to the compression mechanism of the powder bed.

From: A Holistic Multi Evidence Approach to Study the Fragmentation Behaviour of Crystalline Mannitol

Powder

Out-of-die Yield Pressure (MPa)

In-Die Yield Pressure (MPa)

Disintegration Time (s)

Hardness (N)

75 MPa

225 MPa

75 MPa

225 MPa

F0

3333.33

144.47 ± 8.02

35.67 ± 2.08

280.00 ± 8.54

45.70 ± 5.61

120.47 ± 6.59

F1

1250.00

156.19 ± 17.35

52.33 ± 4.16

133.00 ± 6.08*

63.40 ± 10.13

161.80 ± 17.41

F2

714.29

280.88 ± 15.07*

34.33 ± 2.08

125.33 ± 7.51*

52.03 ± 8.79

148.83 ± 5.69

F3

833.33

380.37 ± 38.95*

283.00 ± 8.00*

281.67 ± 6.03

113.00 ± 18.49*

320.53 ± 45.76*

F4

1666.67

229.62 ± 15.20*

126.67 ± 37.90*

190.67 ± 13.61*

93.27 ± 10.17*

243.00 ± 13.95*

F5

1666.67

240.10 ± 31.98*

35.33 ± 2.89

119.00 ± 6.24*

51.13 ± 2.32

155.93 ± 11.16

F6

1250.00

324.26 ± 17.44*

36.67 ± 2.08

128.67 ± 3.51*

47.20 ± 6.68

142.53 ± 7.91

F7

1250.00

202.85 ± 43.75

154.67 ± 10.07*

249.67 ± 6.81

107.10 ± 11.44*

238.10 ± 24.21*

F8

1250.00

226.85 ± 43.21*

57.67 ± 4.73

169.67 ± 23.59*

87.80 ± 0.70*

181.93 ± 44.00

  1. Also displayed are the hardness and disintegration time of ODTs manufactured from milled mannitol powders (F1-F8) compared to the control (F0) at compression forces of 75 and 225 MPa. Data marked with a single asterisk (*) indicates results that are significantly different from the control (ANOVA p < 0.05 when compared to F0).