Figure 4 | Scientific Reports

Figure 4

From: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer

Figure 4

AZD6244 suppresses phosphorylation of ERK in gastric cancer cells.

Phosphorylation of ERK in gastric cancer cell SGC7901 (A) and BGC823 (B) was determined by Western blot. Compared with vehicle treated SGC7901 cells, suppression of ERK phosphorylation was observed in cells treatment with all concentration of AZD6244 (1, 2, 3 and 4 μM) for 24 and 48 hours. Compared with vehicle treated BGC823 cells, ERK phosphorylation was suppressed by treatment with all given concentration of AZD6244 (1, 2, 3 and 4 μM) for 24 and 48 hours. *p < 0.05 vs. vehicle treated cells for 24 hours; # p < 0.05 vs. vehicle treated cells for 48 hours.

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