Figure 2
From: SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
Hypoxia decreases sensitivity of SKOV3 cells to cisplatin.
(A) SKOV3 cells were treated with the indicated concentrations of cisplatin for 48 h in both normoxia and hypoxia. Flow cytometry showed that the cell apoptosis rates in hypoxia were significantly lower than those in normoxia with the same cisplatin concentration (P < 0.01). (B) SKOV3 cells were treated with the indicated concentrations of cisplatin in both normoxia and hypoxia (N = normoxia, H = hypoxia). Cell viability was analyzed by CCK8 assay and the points represented averages of three independent experiments.
