Figure 6
From: Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions
In vivo survival and therapeutic mechanism of LPA-treated CD34+ cells.
(A) Representative transverse heart sections stained with Hematoxylin and Eosin in animals treated with PBS, fibrin gel containing CD34+ cells or LPA-treated CD34+ cells. Samples were collected at week 3 after myocardial infarction. Magnification 40× (A.1) and 400× (A.2). Images in (A.2) are magnifications of regions defined in A.1. (B) Localization (B.1) and number (B.2) of neovessels staining for rat endothelial marker RECA-1 in the infarcted area (n = 3–5). (C) Localization (C.1) and number (C.2) of human CD34+ cells in the heart. In (B,C) scale bar corresponds to 50 μm. *Denotes statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001.
