Figure 7

In vivo therapeutic mechanism of LPA-treated CD34⁺ cells.

After myocardial infarction, left ventricles were treated with PBS, fibrin gel containing CD34⁺ cells or LPA-treated CD34⁺ cells. (A) Representative images of heart rats treated with fibrin gel containing LPA-treated CD34⁺ cells and immunostained for CD206, CD80, Ki-67 and Sca-1. (B) Quantification of staining for CD206 and CD80 in hearts from 3–5 different animals and more than 3 sections for each animal. Score 0, 1, 2 and 3 means that 0%, below 10%, between 10 and 50% and above 50% of the cells stained for the corresponding marker. The quantification was performed by a pathologist. *Denotes statistical significance: *P < 0.05, **P < 0.01.