Figure 3 | Scientific Reports

Figure 3

From: Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations

Figure 3

High magnification assessment of pericyte/endothelial cell interactions.

(A–C) Capillary plexus of P5 retinas whole-mount immunostained for CD31 (red) to mark the endothelium and NG2 (green) to mark pericytes. (A’–C’) Corresponding NG2 staining in grey. Pericytes with abnormal cell morphology marked by white arrows. (D–F) Electron micrographs of retinal capillaries show vessel lumen (L), endothelial cell nuclei (EC) and pericyte nuclei (PC). Scale bars: (A–C) 25 μm, (D–F) 1 μm.

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