Table 2 Association between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and median survival time, median time to progression, and median progression-free survival of platinum-based chemotherapy in advanced lung cancer patients.
Study | Year | Arg194Trp(95%-CI) | Trp/Trp+Trp/Arg | ArgArg | Arg399Gln(95%-CI) | Gln/Gln+Gln/Arg | ArgArg | |||
|---|---|---|---|---|---|---|---|---|---|---|
TrpTrp | TrpArg | GlnGln | GlnArg | |||||||
Cheng et al., | 2011 | MST | — | — | — | — | — | — | 11.10 | 15.20 |
Giachino et al., | 2007 | MST | — | — | — | — | 18.67 | 12.74 | — | 12.97 |
HR | — | — | — | — | 0.60 | 1.17 | — | 1(Reference) | ||
(0.35–1.03) | (0.85–1.59) | |||||||||
de las Penas R. et al., | 2006 | MST | — | — | — | — | 10.56 | 13.95 | — | 10.86 |
(5.03–16.09) | (10.92–16.97) | (7.40–14.31) | ||||||||
HR | — | — | — | — | 1.59 | 1(Reference) | — | 1.51 | ||
(0.81–3.10) | (1.03–2.40) | |||||||||
Gurubhagavatula et al., | 2004 | MST | — | — | — | — | 7.70 | 11.40 | — | 17.30 |
HR | — | — | — | — | 3.17 | 1.22 | — | 1(Reference) | ||
(1.48–6.77) | (0.76–1.94) | |||||||||
Kalikaki et al., | 2009 | MST | — | — | — | — | 7.10 | 11.30 | — | 14.80 |
(0.30–13.90) | (8.90–13.80) | (9.10–20.50) | ||||||||
HR | — | — | — | — | 4.58 | 1.43 | — | 1(Reference) | ||
(1.92–10.92) | (0.85–2.40) | |||||||||
Liu et al., | 2008 | MST | — | — | — | — | 8.00 | 16.00 | — | 24.00 |
(5.90–10.10) | (13.90–18.10 | (16.50–31.50) | ||||||||
HR | — | — | — | — | 6.24 | 1.44 | — | 1(Reference) | ||
(1.86–20.91) | (0.66–3.12) | |||||||||
Han et al., | 2011 | MST | — | — | — | — | — | — | — | — |
HR | — | — | — | — | — | — | 1(Reference) | 1.35 | ||
(0.90–2.00) | ||||||||||
Yao et al., | 2009 | MST | — | — | — | — | 15.00 | 21.00 | — | 29.00 |
(11.90–21.10) | (11.50–30.90) | (7.00–39.00) | ||||||||
HR | 1(Reference) | 0.83 | — | 0.58 | ||||||
(0.49–1.41) | (0.17–2.04) | |||||||||
Yuan et al., | 2010 | MST | 15.00 | 17.00 | 17.00 | 16.00 | 14.00 | 16.00 | 16.00 | 17.00 |
(9.05–20.50) | (14.40–19.90) | (14.60–19.40) | (10.90–21.10) | (5.70–22.30) | (11.40–20.60) | (12.10–19.9) | (13.80–20.20) | |||
HR | 1.23 | 0.94 | 1.00 | 1(Reference) | 1.13 | 1.25 | 1.23 | 1(Reference) | ||
(0.73–2.10) | (0.66–1.34) | (0.71–1.39) | (0.63–2.03) | (0.88–1.79) | (0.88–1.71) | |||||
Wang et al. , | 2006 | MST | — | — | 13.00 | 11.00 | — | — | 10.00 | 14.00 |
Joerger et al., | 2012 | MST | — | — | — | — | 6.00 | 10.40 | — | 10.80 |
(2.30–9.30) | (9.40–13.70) | (7.30–15.90) | ||||||||
HR | — | — | — | — | 1(Reference) | 0.62 | — | 0.56 | ||
(0.34–1.11) | (0.30–1.01) | |||||||||
Zhou et al., | 2014 | MST | — | — | — | — | 10.00 | 12.00 | ||
Yang et al., | 2013 | MST | 14.00 | 10.00 | — | — | — | — | ||
Ke et al., | 2012 | MST | — | — | — | — | — | — | — | — |
HR | 0.45 | 1.23 | — | 1(Reference) | 0.42 | 0.76 | — | 1(Reference) | ||
(0.23–0.87) | (0.81–1.89) | (0.21–0.82) | (0.53–1.07) | |||||||
Lee et al., | 2013 | MST | — | — | — | — | 9.80 | 13.00 | — | 14.40 |
(2.60–17.00) | (11.10–15.00) | (12.70–16.10) | ||||||||
HR | — | — | — | — | 1.47 | 1.13 | — | 1(Reference) | ||
(0.91–2.37) | (0.90–1.42) | |||||||||
Liao et al., | 2012 | MST | — | — | — | — | — | — | — | 22.00 |
(10.00–34.00) | ||||||||||
HR | — | — | — | — | 0.25 | 0.26 | — | 1(Reference) | ||
(0.03–1.88) | (0.11–0.64) | |||||||||
Liao et al., | 2012 | MST | — | — | — | — | — | — | 45.00 | 29.00 |
(36.00–54.00) | (20.00–38.00) | |||||||||
HR | — | — | — | — | — | — | 0.47 | 1(Reference) | ||
(0.25–0.92) | ||||||||||
Zhao et al., | 2013 | MST | 8.50a | 32.00 | — | 14.60a | 5.70a | 36.00 | — | 32.00 |
HR | 1.13 | 0.84 | 0.88 | 1(Reference) | 1.32 | 0.83 | 0.89 | 1(Reference) | ||
(0.30–4.17) | (0.45–1.58) | (0.48–1.61) | (0.43–4.00) | (0.44–1.57) | (0.49–1.62) | |||||
Hong et al., | 2011 | MST | — | — | — | — | — | — | 15.00 | 19.00 |
(8.55–21.45) | (15.00–23.00) | |||||||||
HR | — | — | — | — | — | — | 1.27 | 1(Reference) | ||
(0.93–1.75) | ||||||||||
Peng et al., | 2014 | MST | — | — | — | — | 16.00 | 12.00 | 12.00 | 17.00 |
(0.00–33.53) | (10.03–13.97) | (10.03–13.97) | (14.69–19.31) | |||||||
HR | — | — | — | — | — | — | 1(Reference) | 1.69 | ||
(1.19–2.40) | ||||||||||
Zhang et al., | 2014 | MST | 26.60 | 25.30 | 25.90 | 23.40 | 27.50 | 23.70 | 25.60 | 22.30 |
(14.90–28.80) | (14.40–29.40) | (13.80–29.10) | (14.20–28.50) | (15.80–32.30) | (14.30–27.40) | (15.20–28.20) | (13.50–27.20) | |||
HR | 0.83 | 0.79 | 0.81 | 1(Reference) | 0.48 | 0.74 | 0.55 | 1(Reference) | ||
(0.51–1.62) | (0.55–1.67) | (0.56–1.66) | (0.25–0.86) | (0.48–1.53) | (0.23–0.94) | |||||
Jin | 2014 | MST | — | — | — | — | — | — | — | — |
HR | 0.82 | 0.91 | — | 1(Reference) | 0.51 | 0.87 | — | 1(Reference) | ||
(0.47–1.39) | (0.61–1.33) | (0.26–0.98) | (0.60–1.24) | |||||||
Kalikaki et al., | 2015 | MST | — | — | — | — | — | — | 10.80 | 10.80 |
(7.30–14.30) | (4.60–17.90) | |||||||||
HR | — | — | — | — | — | — | 1.01 | 1(Reference) | ||
(0.64–1.50) | ||||||||||
Liu et al., | 2008 | Median TTP | — | — | — | — | 4.10 | 6.00 | — | 11.00 |
(2.30–5.90) | (3.10–8.90) | (6.40–15.60) | ||||||||
HR | — | — | — | — | 1.91 | 1.00 | — | 1(Reference) | ||
(0.62–5.83) | (0.50–2.04) | |||||||||
Zhou et al., | 2011 | Median TTP | — | — | — | — | — | — | 6.00 | 8.50 |
(5.50–6.50) | (7.86–9.14) | |||||||||
Zhou et al., | 2011 | Median TTP | — | — | — | — | — | — | 6.50 | 7.00 |
(5.90–7.10) | (6.04–7.96) | |||||||||
Han et al., | 2011 | Median TTP | — | — | — | — | — | — | 5.00 | 9.50 |
Yuan et al., | 2010 | Median PFS | 6.80 | 7.00 | 6.80 | 6.90 | 6.90 | 6.90 | 6.90 | 6.80 |
(4.30–9.30) | (6.00–8.00) | (5.60–8.00) | (5.60–8.30) | (2.50–11.30) | (6.00–7.80) | (6.00–7.80) | (5.60–8.00) | |||
HR | 1.31 | 1.10 | 1.14 | 1(Reference) | 0.69 | 1.08 | 0.98 | 1(Reference) | ||
(0.77–2.23) | (0.78–1.57) | (0.82–1.59) | (0.38–1.25) | (0.76–1.53) | (0.71–1.35) | |||||
Joerger et al., | 2012 | Median PFS | — | — | — | — | 4.80 | 6.30 | — | 5.20 |
(1.40–7.30) | (5.30–8.10) | (3.50–7.60) | ||||||||
HR | — | — | — | — | 1(Reference) | 0.91 | — | 1.03 | ||
(0.53–1.58) | (0.59–1.82) | |||||||||
Liao et al., | 2012 | Median PFS | — | — | — | — | 5.10 | 5.10 | — | 5.80 |
(3.10–7.20) | (3.30–7.00) | (4.20–7.40) | ||||||||
Zhao et al., | 2013 | Median PFS | 6.70a | 9.00 | — | 11.50 | 8.00 | 12.00 | — | 10.00 |
HR | 0.56 | 1.12 | — | 1(Reference) | 1.33 | 0.73 | — | 1(Reference) | ||
(0.16–1.95) | (0.70–1.80) | (0.56–3.19) | (0.45–1.19) | |||||||
Deng et al., | 2013 | Median PFS | — | — | — | — | — | — | 6.07 | 6.23 |
HR | — | — | — | — | 0.81 | 1(Reference) | ||||
(0.51–1.27) | ||||||||||
Peng et al., | 2014 | Median PFS | — | — | — | — | 2.00 | 6.00 | 6.00 | 7.00 |
(1.03–2.97) | (4.21–7.80) | (4.33–7.67) | (5.69–8.31) | |||||||
Zhang et al., | 2014 | Median PFS | 9.40 | 8.70 | 8.80 | 8.60 | 10.90 | 8.50 | 10.40 | 7.80 |
(4.20–16.40) | (3.80–15.10) | (4.30–16.30) | (3.40–14.20) | (5.40–18.60) | (3.20–14.20) | (5.10–18.30) | (3.20–13.60) | |||
HR | 0.83 | 0.89 | 0.85 | 1(Reference) | 0.51 | 0.79 | 0.61 | 1(Reference) | ||
(0.42–1.43) | (0.54–1.60) | (0.57–1.59) | (0.23–0.96) | (0.52–1.58) | (0.31–1.22) | |||||
Kalikaki et al., | 2015 | Median PFS | — | — | — | — | — | — | 4.40 | 5.60 |
(3.00–6.10) | (3.20–8.10) | |||||||||
HR | — | — | — | 0.83 | 1(Reference) | |||||
(0.55-1.26) | ||||||||||
