Figure 3

Abnormal distribution of cytoskeleton components in the Spag6-deficient (KO) MEFs during migration.
Upper panels: F-actin distribution; Lower panels. α–tubulin distribution. Notice that in the wild-type MEFs (left panels), both F-actin and α–tubulin distribute to the migrating front area (arrow heads), but this pattern is lost in the Spag6-deficient MEFs. The long arrows show migration direction.