Figure 1
From: TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB and Bnip3 Pathways
Characterization of the inducible cardiac-specific TAK1ΔN transgenic mice at baseline.
(A) Schematic of the bitransgenic inducible expression system used to regulate TAK1ΔN expression in the mouse heart. (B) Western blot for TAK1 and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in cardiac extracts from mice of the indicated genotypes at 3 months of age (off Dox). 2 transgenic lines (11.10 and 13.1) were shown. (C) Western blot for TAK1 protein in the hearts of the indicated mice on Dox (+), off Dox (−), or breeding on Dox until weaning and then off (+/−). (D,E) Heart weight/body weight ratio (HW/BW) and echocardiographic analysis of ventricular fractional shortening (FS) in TAK1ΔN transgenic line 11.10 at 3 months of age. (F,G) HW/BW and FS in TAK1ΔN transgenic line 11.10 at 12 months of age. The number of mice analyzed is shown in the bars of each panel.
