Figure 5
From: TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB and Bnip3 Pathways
TAK1ΔN DTG mice are protected from chronic pressure overload-induced pathological cardiac remodeling and dysfunction.
(A,B) Cardiac fractional shortening (FS) and left ventricular end-diastolic dimension (LVED) from control and DTG mice subjected to TAC or sham procedure for 8 weeks. *P < 0.05 versus corresponding Sham. #P < 0.05 versus Con TAC. (C) Heart weight/body weight ratio (HW/BW) from control and DTG mice indicated in A. Masson trichrome-stained whole heart sections from control and DTG mice subjected to TAC are shown. (D) Myocyte surface area from cardiac sections of the mice indicated in A. (E) Lung weight/body weight ratio (LW/BW) from mice indicated in A. *P < 0.05 versus corresponding Sham. #P < 0.05 versus Con TAC. (F) Masson trichrome-stained, paraffin-embedded cardiac sections from mice indicated in A. (G) Quantitation of cardiac fibrotic area from cardiac sections indicated in F. *P < 0.01 versus corresponding Sham. #P < 0.05 versus Con TAC. (H) TUNEL-positive nuclei in cardiac sections. *P < 0.01 versus corresponding Sham. #P < 0.05 versus Con TAC.
