Figure 6
From: TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB and Bnip3 Pathways
TAK1 activation prevented pathological remodeling and heart failure progression after myocardial infarction.
(A) Survival rates of Con and DTG mice subjected to sham or MI surgical procedure for 4 weeks. *P < 0.05 versus Con MI. (B,C) Echocardiographic analysis of FS and LVED in Con and DTG mice subjected to sham or MI surgical procedure for 4 weeks. *P < 0.05 versus corresponding Sham. #P < 0.05 versus Con MI. (D,E) HW/BW and cell surface area from mice indicated in B. *P < 0.05 versus corresponding Sham. #P < 0.05 versus Con MI. (F) LW/BW from mice indicated in B. *P < 0.05 versus corresponding Sham. #P < 0.05 versus Con MI. (G) Masson’s trichrome-stained histological cardiac sections and quantitation of infarct size from Con or DTG mice subjected to MI or a sham procedure for 4 weeks. *P < 0.05 versus Con. (H) TUNEL-positive nuclei in the cardiac sections from control and DTG mice. *P < 0.01 versus corresponding Sham. #P < 0.05 versus Con MI.
