Figure 2 | Scientific Reports

Figure 2

From: TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation

Figure 2

Higher expression of TMEM16A in HPV-negative patients correlates with decreased survival in TCGA.

(a) Using data from TCGA, mRNA Z-scores for TMEM16A were found to be significantly higher in HPV-negative tumors than HPV-positive ones. (b) Similarly, DNA log2 ratios for TMEM16A gene are significantly higher in HPV-negative tumors than HPV-positive ones. (c) The TMEM16A gene is much more likely to be amplified (defined as log2 ratio > 2) HPV-negative tumors than HPV-positive ones. (d) In patients with HPV-negative HNSCC, overexpression of TMEM16A (defined as mRNA Z-score >2) was associated with significantly decreased survival, a pattern that was not seen with HPV-positive HNSCC (see Supplementary Fig. S1).

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