Figure 4
From: IL-36α: a novel cytokine involved in the catabolic and inflammatory response in chondrocytes
Illustrated summary.
Blue arrows and blue keys represent results obtained in the present study. Green arrows and green keys represent results obtained in other published articles10,11. IL36α produced by immune cells could induce the expression of different pro-inflammatory and pro-catabolic factors in chondrocytes and in synovial fibroblasts. Probably, IL36α also acts in an autocrine or paracrine manner in chondrocytes. Moreover, it was reported that the addition of recombinant IL36β to chondrocytes or synovial fibroblasts was able to induce the expression of different pro-inflammatory mediators.
