Figure 6 | Scientific Reports

Figure 6

From: Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations

Figure 6

Graphic depiction of aa changes in LMP-1 protein.

The positions of 9 common aa changes (resulted from10 nt changes in the coding region) uniquely shared by 11 of 12 BL-EBVs, except VGO, are marked purple. None of these 9 aa common changes are observed in NPC-EBVs. They are located in cytoplasmic domain (2 aa), intramembrane domain (5 aa) and CTAR1 (2 aa) of LMP-1 protein. The positions of 13 common aa changes shared by essentially all 12 BL-EBVs studied as well as NPC-EBVs in NCBI database are marked red. Positions of 10 common aa deletions found in NPC-EBVs are marked yellow. C-terminal activation regions 1–3 (CTAR1-3) of the protein are marked by rectangle.

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