Figure 4 | Scientific Reports

Figure 4

From: Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain

Figure 4

Occurrence of spontaneous activity (SA) in different subsets of nociceptive DRG neurons in CRP rats.

(a) The proportion of cells expressing SA in IB4− Aδ-, IB4− C- or IB4+ C-type DRG neurons in control and CRP rats. (b) Typical example of a spontaneous firing of an IB4− Aδ-type neuron from CRP rats at 3d after surgery. (c) Quantitative analysis of SA frequency in IB4− Aδ-type neurons in control and CRP rats. (d) The time course of a typical example of spontaneous firing observed in IB4− Aδ-type neuron from CRP rats showing frequency (grey column), peak amplitude (filled red circle), RMP (filled black rectangle) and duration of SA. (e) Three firing patterns of SA in IB4− Aδ-type neuron from CRP rats are shown: bursting activity (upper panel), periodic discharges (middle panel) and irregular firing (lower panel). *P < 0.05 indicates statistically significant differences between control and CRP rats (ANOVA).

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