Figure 6 | Scientific Reports

Figure 6

From: Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain

Figure 6

CRP increases Ih currents in IB4− Aδ-, but not in IB4− C- or IB4+ C-type DRG neurons.

(a) Ih current was evoked by hyperpolarizing voltage steps of −50 mV to −120 mV from a holding potential at −60 mV in IB4− Aδ-type DRG neurons. The voltage protocol is shown at the top. (b) Ih current recorded in IB4− Aδ-type DRG neurons was blocked by bath application of Cs2+ (1 mM) or ZD7288 (15 μM). (c) Representative examples of Ih recorded in IB4− Aδ-, IB4− C- and IB4+ C-type DRG neurons from control (upper panels) and CRP rats (lower panels). (d) Only IB4− Aδ-type neurons showed upregulated Ih currents after CRP operation, which is not seen in C-type neurons. All data are expressed as mean ± S.E.M. *P < 0.05 as compared to control rats.

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