Table 3 The protective effects of compound TS-15 and TS-40 against chemically-induced cerebral hemorrhage in zebrafish.

From: Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays

Compounds

Cerebral hemorrhage rate (%)a

 Control

100

TS-15

 60 μM

<60b,*

 2 0μM

73.5 ± 13.0*

 6 μM

79.3 ± 5.9

TS-40

 60 μM

66.2 ± 7.2*

 20 μM

78.8 ± 7.1*

 6 μM

90.6 ± 7.4

Y27632

 10 μM

74.4 ± 8.7*

  1. aThe cerebral hemorrhage rate of each group was calculated by the number of zebrafish with cerebral hemorrhage symptoms to the total number of each group (10 embryos per group);
  2. bObvious mortality and acute toxicity were observed. Data represented the mean ± RSD (n = 4). Statistical comparison of the data was performed by one-way ANOVA followed by Dunnett’s test. *P < 0.05 compared to the control group.
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