Table 4 Percentage of leukocyte populations and cell ratios in nAMD patients with CNV and RAP.

From: Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

    

Univariate analysis

Multivariate analysis (age and gender)

Variables

Controls (mean ± SD) n= 26

CNV (mean ± SD) n= 66

RAP (mean ± SD) n= 13

P value CNV vs RAP 1

P value CNV vs RAP vs controls 2

P value Bonferroni post hoc test

P value CNV vs RAP vs controls 3

Odds ratio

95% confidence interval for odds ratio

Cell subsets (FSC/SSC plot)

 Lymphocytes (%)

30.45 ± 7.82

27.13 ± 7.32

24.62 ± 6.36

0.254

0.047

0.1614 0.0645

   

 Monocytes (%)

7.28 ± 1.88

7.84 ± 2.38

8.44 ± 4.02

0.468

0.382

    

 Neutrophils (%)

59.80 ± 8.73

63.28 ± 7.55

65.35 ± 8.01

0.373

0.075

    

 Neutrophil/Lymphocyte ratio

2.16 ± 0.84

2.62 ± 1.17

2.87 ± 0.96

0.329

0.055

    

Cell subsets (CD antigens)

 CD14+ (%)

7.35 ± 1.95

7.61 ± 2.05

8.45 ± 3.57

0.336

0.472

    

 CD4+ (%)

12.21 ± 3.92

11.88 ± 4.75

10.77 ± 3.02

0.600

0.614

    

 CD8+ (%)

5.86 ± 2.96

5.25 ± 3.66

4.69 ± 2.49

0.978

0.425

    

 CD19+ (%)

3.41 ± 2.16

2.86 ± 1.37

2.19 ± 1.23

0.117

0.110

    

 CD56+ (%)

3.27 ± 1.66

3.50 ± 2.16

3.39 ± 1.71

0.801

0.958

    

 CD11b+ (%)

67.40 ± 9.00

72.00 ± 7.92

76.72 ± 5.42

0.082

0.007

0.0864 0.0095

0.046 4 0.033 5

1.07 1.15

1.00 ± 1.14 1.01 ± 1.30

 CD16hiHLA-DR Neutrophils (%)

57.80 ± 9.05

62.92 ± 8.09

63.26 ± 7.77

0.888

0.025

0.0274 0.1665

0.0154 0.3045

1.08 1.05

1.01 ± 1.14 0.96 ± 1.15

 CD16hiHLA-DR/(CD4 + CD8) ratio

3.51 ± 1.49

4.25 ± 1.92

4.51 ± 1.56

0.487

0.150

    

 CD16hiHLA-DR/CD4 ratio

5.34 ± 2.34

6.26 ± 2.94

6.40 ± 2.16

0.595

0.317

    

 CD16hiHLA-DR/CD8 ratio

13.80 ± 11.28

20.40 ± 18.82

17.00 ± 8.09

0.997

0.221

    

 CD16hiHLA-DR/CD19 ratio

25.69 ± 21.26

31.21 ± 27.79

45.60 ± 40.21

0.131

0.083

    

 CD16hiHLA-DR/CD56 ratio

22.41 ± 11.25

27.33 ± 23.06

23.06 ± 10.91

0.942

0.922

    
  1. Bold P < 0.05; SD: Standard deviation.
  2. 1Independent samples t-test.
  3. 2One-way ANOVA.
  4. 3Multinomial logistic regression corrected for age and gender.
  5. 4Controls vs CNV.
  6. 5Controls vs RAP.