Figure 2 | Scientific Reports

Figure 2

From: The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

Figure 2

Distribution of radioactivity in tumours derived from 18F-FMISO injected mice.

(A) Distribution of radioactivity from 18F-FMISO between a fraction covalently bound to macromolecules and a low-molecular-weight fraction. Data are means ± s.d. (n = 3). (B) Radio-HPLC chromatogram of the low-molecular-weight fraction of FMISO. (C,D) Autoradiograph (ARG) of tissue sections without (C) and with (D) washing. Scale bar represents 1 mm. (E) Immunohistochemical staining for pimonidazole. Scale bar represents 1 mm.

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