Figure 4
From: Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
Crosstalk between Akt and ERK in CSCs migration.
(A) CSCs migration induced by SDF-1 with different inhibitors was detected by transwell migration assay. *P < 0.05 versus control. **P < 0.05 versus SDF-1 group. (B) With ERK inhibitor PD98059, Akt, phospho-Akt, ERK, phospho-ERK and Raf-1 expression were detected by western blot. (C) With Akt inhibitor MK2206, Akt, phospho-Akt, ERK, phospho-ERK and Raf-1 expression were detected by western blot. (D) With RAF-1 inhibitor GW5074, Akt, phospho-Akt, ERK, phospho-ERK and Raf-1 expression were detected by western blot. *P < 0.05 versus SDF-1 group.
