Figure 5
Prognostic performance (C-index, n = 108/AUC, n = 98) for all tumor sub-compartments and composed volumes for the fully automatic segmentation algorithm and manual delineations.
The concordance index (CI) is a generalization of the AUC, which takes into account the time to event and censoring and provides the probability that among two randomly drawn samples, the sample with the higher risk value has also the higher chance of experiencing an event (e.g., death). The symbol * denotes that a CI/AUC is significantly different than random (CI/AUC = 0.5) and was determined using the “noether” method as implemented in the R survcomp package33. Vertical dotted lines indicate confidence intervals for the CI/AUC values. Horizontal solid lines indicate that a performance metric (CI or AUC) is significantly higher for the indicated segmentation method as compared to its counterpart (p < 0.05, p-value from the Student t test for the comparison cindex1 > cindex2 as implemented in the R suvcomp package).
