Table 1 Selected published studies assessing molecules linked to temozolomide resistance in gliomas.

From: Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma

Article

Title

Association

Reference

Huang et al., 2014

The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide

Expression level

55

Epple et al., 2013

Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells

Expression level

56

Bruyère et al., 2011

Temozolomide-induced modification of the CXC chemokine network in experimental gliomas

Expression level

57

Cui et al., 2010

Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.

Functional

58

Yoshino et al., 2010

Gene expression profiling predicts response to temozolomide in malignant gliomas.

Expression level

59

Auger et al., 2006

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Expression level

60

Demuth et al., 2007

MAP-ing glioma invasion: mitogen-activated protein kinase 3 and p38 drive glioma invasion and progression and predict patient survival

Functional

61

Ye et al., 2013

Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.

Expression level

62

Kumar et al., 2013

Temozolomide-modulated glioma proteome: role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivity.

Expression level

63

Happold et al., 2012

Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells

Expression level

64

Zhang et al., 2010

Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.

Functional

65

Gimenez et al., 2012

Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA.

Expression level

66