Table 3 Main functions and pathways enriched in each moduleofthe GeneMania network.
Module | Number of proteins | Main enriched functions and pathways |
|---|---|---|
1 | 97 | MAPK signaling pathway, toll-like receptor cascade, autophagy, cellular senescence |
2 | 84 | apoptosis, DNA damage response, cytoplasmic ribosomal proteins, ATM signaling pathway, regulation of cell cycle progression, p53 pathway |
3 | 94 | amino acid metabolism, unfolded protein response, antigen processing and presentation, ubiquitin-proteasome system |
4 | 17 | Mitotic G1-G2/M phases, centrosome maturation |
5 | 8 | detoxification of reactive oxygen species, cellular response to stress |
6 | 112 | focal adhesion, regulation of actin cytoskeleton, ECM-receptor interaction, cytokine-cytokine receptor interaction, NGF, PDGF, SCF-Kit, DAP12 and PI3K/Akt pathways. |
7 | 16 | apoptosis |
8 | 19 | matrix metalloproteinases, Insulin-like growth factor uptake |
9 | 15 | TGF-β receptor signaling pathway |
10 | 9 | cell cycle and mRNA processing |
