Table 4 Main functions and pathways enriched in each module of the HS network.
Module | Number of proteins | Main enriched functions and pathways |
|---|---|---|
1 | 86 | Cytokine-cytokine receptor interaction, melanoma, JAK-STAT signaling pathway, MAPK signaling pathway, TLR signaling pathway, apoptosis, glioma, ESC Pluripotency Pathways, IL-1 pathway, senescence and autophagy, signaling by ERBB4, SCF-KIT, ERBB2, FGFR andPDGF |
2 | 12 | mRNA processing, Mitotic anaphase, negative regulation of the PI3K/AKT network |
3 | 13 | Tight junction, calcium signaling pathway, signaling pathways in glioblastoma, endothelin pathway, DNA damage response, calcitonin-like ligand receptors, negative regulation of the PI3K/AKT network |
4 | 33 | Regulation of action cytoskeleton, adherens junctions, cell cycle, ATM signaling pathway, TP53 signaling pathway, DNA damage response, EPH-Ephrin signaling |
5 | 55 | ECM receptor interaction, focal adhesion, cell communication, WNT signaling pathway, IL6 and IL3 pathways, TGF-beta signaling pathway, negative regulation of MAPK cascade |
6 | 15 | Ribosome, NOD pathway, translation factors, caspase cascade in apoptosis |
7 | 54 | MAPK signaling pathway, apoptosis, cellular response to stress, toll-like receptor cascade, |
8 | 17 | Notch signaling pathway, calcium signaling pathway, insulin signaling pathway |
