Figure 5 | Scientific Reports

Figure 5

From: Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease

Figure 5

TGY prevented apoptosis induced by rotenone on SH-SY5Y cells.

It was found that (A) Rotenone induced cell death was counteracted by TGY. (B) TGY extract is safe to the SH-SY5Y cells ≤100 μg/mL. (C) Apoptotic cell death, as indicated by unregulated cleaved Caspase-3 and down regulated pro-survival protein Bcl-2, caused by rotenone treatment, was alleviated by TGY. (D,E) The Bcl-2 and cleaved-Caspase 3 levels in different groups were compared by densitometry analysis. *p < 0.05, **p < 0.01, ***p < 0.001 compared with rotenone-intoxicated cells without treatment. Results were obtained from three independent replicates.

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