Figure 2
From: The transcriptional landscape of dorsal root ganglia after sciatic nerve transection
Three distinct transcriptional phases after peripheral nerve injury.
(A) Euclidean distance heatmap between different time points post nerve injury (PNI), as labeled on top and right margins. Arrows indicate 2 nodal transitions. (B) The number of up-regulated (▲) or down-regulated (●) genes at each time point PNI as compared to that at previous time point PNI. (C) Principal component analysis of differentially expressed genes at different time points PNI. (D) Dendrogram of gene expression profiles, as created by hierarchical clustering analysis. The 2 nodal transitions in temporal gene expressions could segregate 3 distinct transcriptional phases within the period of 14 d PNI. For the sake of convenient description, these 3 phases were arbitrarily designated as “a stress response phase”, “a pre-regeneration phase” and “a regeneration phase”, respectively.
