Figure 1 | Scientific Reports

Figure 1

From: Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet

Figure 1

Chronic circadian disruption and high-fat diet increase mouse body weight.

(a) Experimental protocol for environmental circadian disruption and feeding regimens. (b) Mice were weighed once a week and the body weights of mice consuming either the ND or HFD are depicted over the last ten weeks (Week 13 – Week 22) of the experimental period. HFD diet had a significant impact on body weight (***, Diet: P = 0.005, Diet x Time Interaction: P < 0.0001). There was also a significant circadian rhythm disruption x time interaction on body weight (P = 0.046).

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