Figure 4
SiO2 induced p53 and PUMA expression in HPF-a via the MAPK and PI3K/Akt pathways.
(A) Representative Western blot showing that p53 and PUMA expression induced by SiO2 was attenuated by pretreating HPF-a with an inhibitor of MAPKs or PI3K/Akt. Densitometric analyses of p53 (B) and PUMA (C) expression from five separate experiments. *p < 0.05 vs the control group; #p < 0.05 vs the SiO2 group. (D) MTT assay showing that SiO2 increased the viability of HPF-a in a time-dependent manner. *p < 0.05 vs the control group at the corresponding time point.
