Figure 6
p53 and PUMA mediated HPF-a migration induced by SiO2 in 2D cultures.
(A) Representative images showing that SiO2 induced the migration of GFP-labeled HPF-a cultured as a monolayer. Scale bar = 80 μm. (B) Quantification of the scratch gap distance from six separate experiments. *p < 0.05 vs the control group at the corresponding time point. (C) Representative images showing that SiO2-induced cell migration was abolished by RNAi of p53 or PUMA. Scale bar = 80 μm. (D) Quantification of the scratch gap distance from six separate experiments. *p < 0.05 vs the control siRNA-treated group at the corresponding time point.
