Table 4 Univariate and multivariate Cox regression analyses of disease-free survival in 92 NSCLC patients following surgery.

From: DNA methylation mediated silencing of microRNA-145 is a potential prognostic marker in patients with lung adenocarcinoma

Parameters

Univariate analysis

Multivariable analysis

HR

95% CI

P value

HR

95% CI

P value

Age ( > 60)

1.917

1.144–3.213

0.014

1.863

1.076–3.226

0.026

Gender (male)

1.070

0.603–1.901

0.816

—

—

—

Tumor diameter ( > 3 m)

1.113

0.653–1.897

0.695

—

—

—

Pleural invasion (Positive)

1.631

0.950–2.800

0.076

—

—

—

Lymph node metastasis (Positive)

2.402

1.430–4.033

0.001

1.499

0.802–2.802

0.205

TNM stage (II and III)

2.286

1.367–3.823

0.002

1.536

0.847–2.785

0.158

Histologic grade (M-L and L)

2.499

1.415–4.411

0.002

1.714

0.937–3.135

0.080

miR-145 level (Low)

2.182

1.286–3.701

0.003

1.833

1.048–3.206

0.034

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