Figure 1 | Scientific Reports

Figure 1

From: Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Figure 1

GLPP protected kidneys against RIRI.

C57BL/6J male mice were intraperitoneally administered with vehicle or GLPP (100 mg/kg) daily for 7 days before surgery. Blood and kidney samples were collected for renal function tests and histological examination after reperfusion for 24 h. (A) BUN. (B) Blood creatinine. (C) Representative images of kidney tissue with H & E staining (magnification 400×). (D) Quantification of tubular injury. GLPP was intraperitoneally administered at the beginning of reperfusion to explore the therapeutic effect on IR. After reperfusion for 24 hours, blood and kidney samples were collected for analysis. (E) BUN in mice with GLPP post-treatment. (F) Blood creatinine in mice with GLPP post-treatment. (G) Representative images of kidney tissue with H & E staining in mice with GLPP post-treatment (magnification 400× ). (H) Quantification of tubular injury with GLPP post-treatment. Black arrows: tubular brush border loss and dilatation; Blue arrows: intertubular haemorrhage. Data are presented as the mean ± SEM (n = 8–10). *P < 0.05, **P < 0.01.

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