Figure 2
From: Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis
Deterioration of liver fibrosis in Gpnmb−/− mice under HFHS chow.
(a,b) Liver weight and triglyceride contents of Gpnmb−/− and Gpnmb+/+ mice under HFHS chow. (c,d) Liver fibrosis areas and serum alanine aminotransferase (ALT) levels of Gpnmb−/− and Gpnmb+/+ mice under HFHS chow. (e) Periodic acid-Schiff (PAS) staining (left panels) and Azan-Mallory staining (right panels) of liver tissues of Gpnmb−/− and Gpnmb+/+ mice under HFHS chow. (f) Analyses of inflammation, fibrosis and fatty acid synthesis-related genes. mRNA levels of liver tissues of Gpnmb−/− and Gpnmb+/+ mice under HFHS chow by quantitative real-time PCR. All data are presented as mean ± standard deviation (SD) n = 8. **p < 0.01 v.s. Gpnmb+/+ mice.
