Table 2 Binding affinity of 2870.

From: Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

2870

Target

IC50 (μM)

BRD4(1)

9.02

EGFR (ERBB1)

0.044

ERBB2

8.73

ERBB4

24.2

  1. Activity of compound 2870 against BRD4(1) by alpha screen and EGFR TKD and other related kinase family members obtained by kinase activity enzyme profiling.
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