Figure 6 | Scientific Reports

Figure 6

From: Role of P38 MAPK on MMP Activity in Photothrombotic Stroke Mice as Measured using an Ultrafast MMP Activatable Probe

Figure 6

Inhibition of p38 MAPK improved stroke recovery.

(A) Western blotting of phosphorylated-p38 MAPK (p-p38) and total-p38 MAPK (T-p38) and (B) quantitative analysis of the ratio of p-p38/T-p38 on days 0, 2, 7 and 14 with vehicle (Veh) or RWJ67657 (RWJ) administration. (C) T2-weighted images and (D) related quantification of infarct size in the ischemic brain after Veh or RWJ treatment. (E) mNSS score and (F) foot-fault analyses in stroke mice (n = 6 per group). *P < 0.05; **P < 0.01.

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