Figure 1 | Scientific Reports

Figure 1

From: Autophosphorylation at Thr279 of Entamoeba histolytica atypical kinase EhAK1 is required for activity and regulation of erythrophagocytosis

Figure 1

Domain organization and multiple sequence alignment of the kinase domain of EhAK1.

(A) Schematic representation of domain organization of EhAK1. EhAK1 is a 50 kDa protein with two domains, alpha kinase domain (38–267 amino acids) and SH3 domain (322–380 amino acids). (B) Alignment of the sequences of kinase domains of EhAK1, MHCK-A, MHCK-B, EF2 K and TRPM7. The kinase domains of EhAK1, MHCK-A, MHCK-B, EF2 K and TRPM7 (UniprotKB accession codes C4M9G9, P42527, P90648, 000918 and Q923J1, respectively) were aligned on the basis of similarities in their sequence. Sequences representing P-loop, N/D loop, G-rich region and Zinc finger motif are indicated. Invariant K85 that is predicted to be involved in nucleoside binding site is also shown. Identical residues in EhAK1 are shown in white text on a blue background.

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