Figure 1 | Scientific Reports

Figure 1

From: Non-cultured dermal-derived mesenchymal cells attenuate sepsis induced by cecal ligation and puncture in mice

Figure 1

Non-cultured DMCs treatment improved the survival and decreased intestinal damage after CLP in mice (A) Non-cultured DMCs treatment significantly reduced mortality in septic mice.

Survival rate following CLP -induced sepsis in mice treated with DMCs (n = 37) or saline (n = 38). Kaplan-Meier curves represent survival rate in the 2 groups. Survival rate was significantly higher in the DMCs group than the saline groups: *P < 0.05, DMCs vs. saline. (B) Hematoxylin and eosin were used to stain ileocecal region tissues from representative animals 7 days after CLP. Transplantation of DMCs reduced inflammatory cell infiltration (indicated by black arrowhead) and exudation (indicated by blue arrowhead) after CLP. The ileocecal region was fixed with 4% paraformaldehyde, embedded in paraffin and cut into 5-μm-thick sections before stained. (C) Apoptosis was assessed by TUNEL staining 2 days after CLP. CLP -induced sepsis also increased the percentage of apoptotic cells in the lung and treatment with DMCs reduced apoptotic cells to the levels observed in sham-operated animals.

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