Figure 2 | Scientific Reports

Figure 2

From: Non-cultured dermal-derived mesenchymal cells attenuate sepsis induced by cecal ligation and puncture in mice

Figure 2

Non-cultured DMCs can modulate serum cytokine secretion after CLP operation.

Sepsis was induced in male C57Bl/6J mice by cecal ligation and puncture (CLP). Saline or a suspension of non-cultured DMCs (2 × 106 cells in 100 μl of saline) was slowly infused via the tail vein 4 hours after CLP operation. Serum concentrations of IL-1β, IL-6, IL-5, IL-4, IL-10 and IFN-γ were measured after CLP or CLP and DMCs treatment. Serum concentrations of IL-1β (A), IL-6 (B), IL-5 (C), IL-4 (D), IL-10 (E) and IFN-γ (F) at 24h after CLP. n = 5–6 at each group. Error bars represent means ± SD. * indicates Independent-Samples t-test p-values < 0.05. NS means no significant difference.

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